The Anti-TCF1/TCF7 Antibody (CAB20835) is a valuable tool for researchers studying TCF1/TCF7, transcription factors involved in key signaling pathways controlling cell fate and differentiation. This polyclonal antibody, generated in rabbits, is highly specific to TCF1/TCF7 and is validated for use in various applications such as Western blot and immunohistochemistry.TCF1/TCF7, also known as T cell factor 1, plays a critical role in regulating gene expression and determining cell fate in T cells. Dysregulation of TCF1/TCF7 signaling has been implicated in various diseases, including cancer and autoimmune disorders.
Understanding the function and activity of TCF1/TCF7 is essential for unraveling the complexities of these diseases and developing targeted therapies.With its high specificity and sensitivity, the Anti-TCF1/TCF7 Antibody (CAB20835) is an indispensable tool for researchers investigating the role of TCF1/TCF7 in health and disease. Its ability to detect and analyze TCF1/TCF7 in various cell types makes it a valuable asset for studies in immunology, oncology, and molecular biology. Trust this antibody to provide reliable and reproducible results for your research endeavors.
Product Name:
TCF1/TCF7 Monoclonal Antibody
SKU:
CAB20835
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TCF1/TCF7 (NP_003193.2).
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.
Purification Method:
Affinity purification
Gene ID:
6932
Clone Number:
ARC51870
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TCF1/TCF7 Rabbit mAb (CAB20835) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
