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TAB3 Rabbit Monoclonal Antibody (CAB19824)

SKU:
CAB19824
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MAP3K7IP3
NAP1
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TAB3 Rabbit Monoclonal Antibody
SKU:CAB19824
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TAB3 (Q8N5C8).
Sequence:MAQS SPQL DIQV LHDL RQRF PEIP EGVV SQCM LQNN NNLE ACCR ALSQ ESSK YLYM EYHS PDDN RMNR NRLL HINL GIHS PSSY HPGD GAQL NGGR TLVH
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:NAP1; MAP3K7IP3; TAB3
Positive Sample:HeLa,293T,HepG2,Mouse liver
Conjugate:Unconjugated
Cellular Localization:Cytosol, extracellular exosome, plasma membrane
Calculated MW:79kDa
Observed MW:100kDa

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Purification Method:Affinity purification
Gene ID:257397
Clone Number:ARC2350
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using TAB3 antibody (CAB19824) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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