The TAB3 Polyclonal Antibody (CAB19824) is an essential tool for researchers studying the TAB3 protein, a key player in the TAK1 signaling pathway involved in immune responses and inflammation regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to TAB3, this antibody enables the accurate detection and analysis of the protein in various cell types, making it an invaluable asset for immunology and cancer research projects.TAB3, also known as TGF-beta-activated kinase-binding protein 3, is a crucial mediator of pro-inflammatory signaling cascades, making it a promising target for therapeutic intervention in diseases characterized by dysregulated immune responses.
Research on TAB3's role in immune regulation is essential for the development of new treatments for conditions such as cancer, autoimmune disorders, and chronic inflammatory diseases. By understanding the mechanisms by which TAB3 influences immune function, researchers can pave the way for novel therapies aimed at modulating immune responses for improved patient outcomes.
Product Name:
TAB3 Rabbit Monoclonal Antibody
SKU:
CAB19824
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TAB3 (Q8N5C8).
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
257397
Clone Number:
ARC2350
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TAB3 antibody (CAB19824) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
