The Anti-Syntrophin alpha 1 Antibody (CAB20460) is a valuable tool for researchers studying the role of Syntrophin alpha 1 in various biological processes. Syntrophin alpha 1 is a cytoplasmic protein that plays a key role in the organization of signaling proteins at the plasma membrane. This antibody, raised in rabbits, is highly specific and reacts with human samples, making it an ideal choice for experiments involving Syntrophin alpha 1.This antibody is validated for use in Western blot applications, allowing for the detection and analysis of Syntrophin alpha 1 in different cell types and tissues. Its ability to bind to the Syntrophin alpha 1 protein enables researchers to study its function and localization, providing insights into its role in cellular signaling pathways.
Studies have shown that Syntrophin alpha 1 is involved in multiple biological processes, including cell adhesion, migration, and signaling. Dysregulation of Syntrophin alpha 1 has been linked to various diseases, such as muscular dystrophy and cancer. By using this antibody, researchers can further investigate the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the Anti-Syntrophin alpha 1 Antibody (CAB20460) is a valuable tool for researchers interested in unraveling the complexities of Syntrophin alpha 1 biology and its implications in health and disease. Its high specificity and versatility make it suitable for
Product Name:
Syntrophin alpha 1 Rabbit Polyclonal Antibody
SKU:
CAB20460
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human Syntrophin alpha 1 (NP_003089.1).
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
Purification Method:
Affinity purification
Gene ID:
6640
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Syntrophin alpha 1 antibody (CAB20460) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
