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Syntrophin alpha 1 Rabbit Polyclonal Antibody (CAB20460)

SKU:
CAB20460
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LQT12
SNT1
TACIP1
dJ1187J4.5
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Syntrophin alpha 1 Rabbit Polyclonal Antibody
SKU:CAB20460
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human Syntrophin alpha 1 (NP_003089.1).
Sequence:MASG RRAP RTGL LELR AGAG SGAG GERW QRVL LSLA EDVL TVSP ADGD PGPE PGAP REQE PAQL NGAA EPGA GPPQ LPEA LLLQ RRRV TV
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:100 - 1:500 IF/ICC,1:50 - 1:200
Synonyms:SNT1; LQT12; TACIP1; dJ1187J4.5; Syntrophin alpha 1
Positive Sample:HeLa,RD,Mouse skeletal muscle,Mouse brain,Mouse heart,Rat skeletal muscle,Rat kidney,Rat heart
Conjugate:Unconjugated
Cellular Localization:cytoplasm, cytoskeleton, neuromuscular junction, postsynaptic membrane, synapse
Calculated MW:54kDa
Observed MW:59kDa

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

Purification Method:Affinity purification
Gene ID:6640
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using Syntrophin alpha 1 antibody (CAB20460) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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