The Anti-Syntrophin Alpha 1 Antibody (CAB19759) is a specialized tool for research involving Syntrophin Alpha 1, a protein involved in cell signaling and membrane organization. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the Syntrophin Alpha 1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cell biology and neuroscience.Syntrophin Alpha 1 plays a crucial role in anchoring signaling proteins to the cell membrane, helping to organize and regulate various cellular processes.
Its involvement in neuronal signaling and muscle function makes it a key target for research into neurological disorders, muscular dystrophy, and other related conditions. Understanding the function of Syntrophin Alpha 1 is essential for developing new therapies and treatments that target these pathways, offering potential insights into disease mechanisms and therapeutic intervention strategies.
Product Name:
Syntrophin alpha 1 Rabbit Monoclonal Antibody
SKU:
CAB19759
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Syntrophin alpha 1 (Q13424).
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
Purification Method:
Affinity purification
Gene ID:
6640
Clone Number:
ARC2286
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Syntrophin alpha 1 Rabbit mAb (CAB19759) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
