Syntrophin alpha 1 Rabbit Monoclonal Antibody (CAB19759)
- SKU:
- CAB19759
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LQT12
- SNT1
- TACIP1
- dJ1187J4.5
Description
Product Name: | Syntrophin alpha 1 Rabbit Monoclonal Antibody |
SKU: | CAB19759 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Syntrophin alpha 1 (Q13424). |
Sequence: | MASG RRAP RTGL LELR AGAG SGAG GERW QRVL LSLA EDVL TVSP ADGD PGPE PGAP REQE PAQL NGAA EPGA GPPQ LPEA LLLQ RRRV TVRK ADAG GLGI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SNT1; LQT12; TACIP1; dJ1187J4.5; Syntrophin alpha 1 |
Positive Sample: | HeLa,HepG2,C6,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytoskeleton, neuromuscular junction, postsynaptic membrane, synapse |
Calculated MW: | 54kDa |
Observed MW: | 59kDa |
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
Purification Method: | Affinity purification |
Gene ID: | 6640 |
Clone Number: | ARC2286 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |