The SynGAP Monoclonal Antibody (CAB19581) is a powerful tool for studying the SynGAP protein, a crucial regulator of synaptic function in the brain. This antibody, derived from mouse hybridoma cells, is highly specific to human samples and is suitable for use in immunohistochemistry and immunofluorescence experiments.SynGAP is a key player in neuronal signaling pathways, influencing processes such as synaptic plasticity, learning, and memory. Dysregulation of SynGAP expression has been implicated in neurodevelopmental disorders such as intellectual disability and epilepsy, making it a compelling target for research in neuroscience and neurology.
By using the SynGAP Monoclonal Antibody, researchers can effectively visualize and quantify SynGAP expression in neuronal cells and tissues, helping to unravel its role in cognitive function and neurological disorders. This antibody provides a reliable tool for investigating the molecular mechanisms underlying SynGAP-mediated synaptic transmission, paving the way for potential therapeutic interventions in neurological conditions linked to SynGAP dysfunction.
Product Name:
SynGAP Rabbit Monoclonal Antibody
SKU:
CAB19581
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1244-1343 of human SynGAP (Q96PV0).
Cytosol, dendritic shaft, Glutamatergic synapse, plasma membrane, Postsynaptic density
Calculated MW:
148kDa
Observed MW:
140kDa
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8831
Clone Number:
ARC2183
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SynGAP Rabbit mAb (CAB19581) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
