The Anti-Synapsin II Antibody (CAB19542) is a high-quality tool for researchers studying synapsin II, a critical protein involved in regulating neurotransmitter release and synaptic vesicle dynamics in the brain. Synapsin II is known for its role in synaptic plasticity and neurotransmission, making it a key target for studies in neuroscience and neurobiology.This polyclonal antibody, produced in rabbits, offers high reactivity and specificity for detecting synapsin II in human samples, making it an essential tool for Western blot applications. By targeting the synapsin II protein, researchers can analyze its expression and localization in various neuronal cell types, aiding in the understanding of synaptic function and communication in the brain.
Furthermore, the Anti-Synapsin II Antibody is crucial for exploring the involvement of synapsin II in neurological disorders such as Alzheimer's disease, Parkinson's disease, and epilepsy. By investigating the role of synapsin II in these conditions, researchers can uncover potential therapeutic targets and strategies for treating synaptic dysfunction and neuronal communication deficits.
Product Name:
Synapsin II Rabbit Monoclonal Antibody
SKU:
CAB19542
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human Synapsin II (Q92777).
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction.
Purification Method:
Affinity purification
Gene ID:
6854
Clone Number:
ARC2166
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using Synapsin II Rabbit mAb (CAB19542) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
