The Supt5h/Spt5 Antibody (CAB19225) is a valuable tool for researchers studying the Supt5h/Spt5 protein, which plays a crucial role in gene regulation and transcription elongation. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.Supt5h/Spt5 is a key component of the DSIF (DRB-sensitivity inducing factor) complex, which facilitates the elongation phase of RNA polymerase II transcription. Dysregulation of this process has been linked to various diseases, including cancer and developmental disorders.
By targeting Supt5h/Spt5, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.With its ability to detect and analyze Supt5h/Spt5 expression in various cell types, the CAB19225 antibody is an indispensable tool for studies in molecular biology, genetics, and disease pathology. By understanding the function of Supt5h/Spt5, researchers can advance our knowledge of gene expression regulation and potentially uncover new strategies for treating a range of human diseases.
Product Name:
SUPT5H/SPT5 Rabbit Monoclonal Antibody
SKU:
CAB19225
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human SUPT5H/SPT5 (O00267).
Enables enzyme binding activity and protein heterodimerization activity. Involved in positive regulation of macroautophagy; regulation of RNA metabolic process; and transcription elongation from RNA polymerase II promoter. Located in nucleoplasm. Part of DSIF complex.
Purification Method:
Affinity purification
Gene ID:
6829
Clone Number:
ARC2380
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using SUPT5H/SPT5 Rabbit mAb (CAB19225) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
