SUN2 Rabbit Monoclonal Antibody (CAB19782)
- SKU:
- CAB19782
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- UNC84B
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | SUN2 Rabbit Monoclonal Antibody |
SKU: | CAB19782 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 618-717 of human SUN2 (Q9UH99). |
Sequence: | RIRP TAVT LEHV PKAL SPNS TISS APKD FAIF GFDE DLQQ EGTL LGKF TYDQ DGEP IQTF HFQA PTMA TYQV VELR ILTN WGHP EYTC IYRF RVHG EPAH |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 |
Synonyms: | UNC84B; rab5IP; SUN2 |
Positive Sample: | HeLa,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Nuclear envelope, Nuclear membrane |
Calculated MW: | 80kDa |
Observed MW: | 80kDa |
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).
Purification Method: | Affinity purification |
Gene ID: | 25777 |
Clone Number: | ARC2311 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |