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STK33 Rabbit Monoclonal Antibody (CAB19803)

SKU:
CAB19803
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:STK33 Rabbit Monoclonal Antibody
SKU:CAB19803
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 399-514 of human STK33 (Q9BYT3).
Sequence:KEWK NNPE SVEE NTTE EKNK PSTE EKLK SYQP WGNV PDAN YTSD EEEE KQST AYEK QFPA TSKD NFDM CSSS FTSS KLLP AEIK GEME KTPV TPSQ GTAT KYPA KSGA LSRT KKKL
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:STK33
Positive Sample:SH-SY5Y
Conjugate:Unconjugated
Cellular Localization:cytoplasm, nucleus, perinuclear region of cytoplasm
Calculated MW:58kDa
Observed MW:65kDa

Serine/threonine protein kinase (STK33) is a 524-residue kinase that belongs to the calcium/calmodulin-dependent family of kinases. STK33 exhibits differential expression in normal and malignant cancer tissue, including hepatocellular carcinoma. STK33 expression is required in the context of mutant KRAS, the most commonly mutated human oncogene, to maintain for cellular viability and proliferation. STK33 depletion via modulation of interacting proteins results in proteasome-mediated degradation of STK33 in human cancer cells, triggering apoptosis.

Purification Method:Affinity purification
Gene ID:65975
Clone Number:ARC2330
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of SH-SY5Y cells, using STK33 Rabbit mAb (CAB19803) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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