The STIP1 Polyclonal Antibody (CAB0036) is a valuable tool for research focused on the STIP1 protein, a molecular chaperone known to play a role in protein folding and trafficking within cells. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the STIP1 protein, this antibody enables accurate detection and analysis across various cell types, making it well-suited for studies in cell biology, molecular biology, and neurodegenerative diseases.
STIP1, also known as stress-induced phosphoprotein 1, is involved in a variety of cellular processes, including protein folding, signal transduction, and cytoskeletal organization. Dysregulation of STIP1 has been linked to diseases such as neurodegenerative disorders, cancer, and autoimmune diseases, making it a promising target for therapeutic intervention. Research into the functions of STIP1 is essential for advancing our understanding of cellular mechanisms and developing targeted treatments for related pathologies.
Product Name:
STIP1 Rabbit Monoclonal Antibody
SKU:
CAB0036
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2-98 of human STIP1 (P31948).
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).
Purification Method:
Affinity purification
Gene ID:
10963
Clone Number:
ARC1805
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using STIP1 Rabbit mAb (CAB0036) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
