The STIM1 Polyclonal Antibody (CAB9764) is a valuable tool for researchers studying STIM1, a key protein involved in calcium signaling and immune cell activation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for a variety of experimental techniques, including Western blotting.STIM1 plays a pivotal role in the activation of immune cells by regulating calcium influx, a crucial event in immune response initiation. Dysregulation of STIM1 signaling has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer.
As such, research on STIM1 function and regulation is essential for developing targeted therapies for these diseases.With its reliability and specificity in detecting STIM1 protein, the CAB9764 antibody is an indispensable tool for researchers investigating the role of STIM1 in immune cell activation and its implications in disease pathogenesis. Its application extends to a wide range of studies in immunology and cancer research, providing valuable insights into the intricate mechanisms of immune response modulation.
Product Name:
STIM1 Rabbit Monoclonal Antibody
SKU:
CAB9764
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 586-685 of human STIM1 (Q13586).
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6786
Clone Number:
ARC1738
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat testis cells, using STIM1 antibody (CAB9764) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
