STIM1 Rabbit Monoclonal Antibody (CAB9764)
- SKU:
- CAB9764
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- D11S4896E
- GOK
- IMD10
- STRMK
- TAM
- TAM1
Description
Product Name: | STIM1 Rabbit Monoclonal Antibody |
SKU: | CAB9764 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 586-685 of human STIM1 (Q13586). |
Sequence: | LNHG LDKA HSLM ELSP SAPP GGSP HLDS SRSH SPSS PDPD TPSP VGDS RALQ ASRN TRIP HLAG KKAV AEED NGSI GEET DSSP GRKK FPLK IFKK PLKK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | GOK; TAM; TAM1; IMD10; STRMK; D11S4896E; STIM1 |
Positive Sample: | HeLa,BxPC-3,Mouse testis,Mouse brain,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cortical endoplasmic reticulum, Endoplasmic reticulum, Plasma membrane, Plasma membrane raft |
Calculated MW: | 77kDa |
Observed MW: | 85kDa |
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 6786 |
Clone Number: | ARC1738 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |