STAT6 Rabbit Polyclonal Antibody (CAB0755)
- SKU:
- CAB0755
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | STAT6 Rabbit Polyclonal Antibody |
SKU: | CAB0755 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 550-650 of human STAT6 (NP_003144.3). |
Sequence: | LLLN EPDG TFLL RFSD SEIG GITI AHVI RGQD GSPQ IENI QPFS AKDL SIRS LGDR IRDL AQLK NLYP KKPK DEAF RSHY KPEQ MGKD GRGY VPAT IKMT V |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | STAT6B; STAT6C; D12S1644; IL-4-STAT; STAT6 |
Positive Sample: | HeLa,Jurkat,PC-12,NIH/3T3,Mouse lung,Mouse spleen,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 94kDa |
Observed MW: | 110kDa |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 6778 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |