The Anti-SPOP Antibody (CAB19578) is a valuable tool for researchers studying the SPOP protein, an essential component in cancer biology and potential target for therapeutic intervention. This polyclonal antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications. By binding to the SPOP protein, researchers can effectively analyze and detect its expression in various cell types, providing valuable insights into its role in cancer progression and therapeutic resistance.SPOP, also known as Speckle-type POZ protein, is a key regulator of protein degradation and stability, influencing various cellular processes such as cell growth, proliferation, and differentiation.
Dysregulation of SPOP has been implicated in several types of cancer, including prostate, endometrial, and colorectal cancer, highlighting its potential as a therapeutic target. By understanding the mechanisms underlying SPOP function, researchers can develop novel treatment strategies to combat cancer and improve patient outcomes.Overall, the Anti-SPOP Antibody (CAB19578) serves as a powerful tool for investigating the role of SPOP in cancer biology and developing targeted therapies for cancer treatment. Its high specificity and reactivity make it an essential component of research in oncology and drug development.
Product Name:
SPOP Rabbit Monoclonal Antibody
SKU:
CAB19578
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SPOP (O43791).
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
8405
Clone Number:
ARC2181
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of PC-3 cells, using SPOP Rabbit mAb (CAB19578) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
