The Anti-SPINK5/LEKTI Antibody (CAB20916) is a crucial tool for researchers studying SPINK5, a protein involved in maintaining skin barrier function and regulating protease activity. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in various applications including immunofluorescence and flow cytometry.SPINK5, also known as LEKTI, is a key player in skin barrier function and is associated with diseases such as Netherton syndrome, a rare genetic disorder characterized by skin abnormalities.
By targeting SPINK5, researchers can gain insights into the molecular mechanisms underlying skin disorders and explore potential therapeutic strategies to address them.With its ability to detect and analyze SPINK5 in different cell types, the Anti-SPINK5/LEKTI Antibody is an essential tool for studies in dermatology, skin biology, and disease pathogenesis. By understanding the role of SPINK5, researchers can potentially uncover new avenues for treating skin conditions and improving patient outcomes.
Product Name:
SPINK5/LEKTI Monoclonal Antibody
SKU:
CAB20916
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SPINK5 / LEKTI (Q9NQ38).
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11005
Clone Number:
ARC2888
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SPINK5 / LEKTI Rabbit mAb (CAB20916) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
