The Anti-Spermine Synthase Antibody (CAB9380) is an essential tool for research involving spermine synthase, an enzyme involved in the biosynthesis of spermine, a polyamine important for cell growth and differentiation. The antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the spermine synthase protein, allowing for accurate detection and analysis in various cell types, making it ideal for studies in biochemistry and cancer research.Spermine synthase plays a crucial role in polyamine metabolism, which is essential for cell proliferation and survival.
Dysregulation of this enzyme has been implicated in various diseases, including cancer and neurodegenerative disorders. Understanding the function and regulation of spermine synthase is important for developing targeted therapies that modulate polyamine levels in disease states. The Anti-Spermine Synthase Antibody provides researchers with a valuable tool for investigating the role of this enzyme in health and disease.
Product Name:
Spermine synthase Monoclonal Antibody
SKU:
CAB9380
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Spermine synthase (P52788).
This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6611
Clone Number:
ARC2747
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using (CAB9380) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
