The Anti-Sp7 Antibody (CAB18699) is a polyclonal antibody designed for research involving Sp7, a key transcription factor involved in osteoblast differentiation and bone formation. This antibody, produced in rabbits, is highly specific and reactive with human, mouse, and rat samples, making it suitable for a wide range of research applications.Sp7, also known as Osterix, plays a crucial role in regulating the differentiation of mesenchymal stem cells into osteoblasts, the cells responsible for bone formation. Understanding the role of Sp7 in bone development and remodeling is essential for developing new therapies for bone-related diseases such as osteoporosis and osteogenesis imperfecta.
The Anti-Sp7 Antibody (CAB18699) is validated for use in immunohistochemistry, western blot, and other research techniques, allowing for reliable detection and analysis of Sp7 expression in different tissues and cell types. Researchers studying bone biology, skeletal development, and bone diseases will find this antibody to be a valuable tool for their studies.
Product Name:
SP7 Rabbit Polyclonal Antibody
SKU:
CAB18699
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 333-376 of human SP7 (NP_001166938.1).
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
Purification Method:
Affinity purification
Gene ID:
121340
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of U2OS cells, using SP7 antibody (CAB18699) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
