The SOX10 Polyclonal Antibody (CAB8655) is a crucial tool for research involving SOX10, a transcription factor essential for the development of neural crest cells and the differentiation of melanocytes and Schwann cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunohistochemistry and Western blot.SOX10 plays a critical role in neural crest development and melanocyte differentiation, making it a key player in melanoma, neuroblastoma, and other diseases related to neural crest cell dysfunction.
By targeting SOX10, researchers can gain valuable insights into these conditions and potentially uncover new therapeutic approaches.The versatility and specificity of the SOX10 Polyclonal Antibody make it an invaluable tool for researchers in the fields of developmental biology, oncology, and neurology. Its ability to detect and quantify SOX10 expression in different cell types makes it a valuable asset in studying the role of SOX10 in various physiological and pathological processes.
Product Name:
SOX10 Rabbit Monoclonal Antibody
SKU:
CAB8655
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SOX10 (P56693).
HeLa,HT-29,SH-SY5Y,Mouse large intestine,Mouse brain,Mouse heart,Rat brain,Rat heart
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus, Mitochondrion outer membrane
Calculated MW:
50kDa
Observed MW:
62kDa
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
Purification Method:
Affinity purification
Gene ID:
6663
Clone Number:
ARC1767
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SOX10 Rabbit mAb (CAB8655) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
