The Anti-Slit2 Antibody (CAB3467) is a valuable tool for researchers studying the Slit2 protein, a key player in developmental processes and cell migration. This polyclonal antibody, raised in rabbits, is highly specific to Slit2 and is validated for use in a variety of applications, including immunohistochemistry and immunocytochemistry.Slit2 is a secreted protein that plays a crucial role in axon guidance, tissue morphogenesis, and angiogenesis. It is known to interact with several receptors, including Robo1 and Robo2, to mediate cellular responses.
By targeting Slit2 with this antibody, researchers can gain insights into its functions and mechanisms of action in both normal development and disease pathology.The Anti-Slit2 Antibody is a valuable tool for studying the molecular pathways regulated by Slit2 and its role in various physiological and pathological conditions. Its high specificity and reactivity make it an ideal choice for researchers interested in unraveling the complexities of Slit2 signaling and its potential therapeutic applications.
Product Name:
Slit2 Rabbit Monoclonal Antibody
SKU:
CAB3467
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1400-1500 of human Slit2 (O94813).
This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9353
Clone Number:
ARC2010
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Slit2 Rabbit mAb (CAB3467) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
