The Anti-SLFN11 Antibody (CAB20809) is a powerful tool for researchers studying SLFN11, a key protein involved in DNA damage response and sensitivity to DNA-damaging agents. This antibody, generated in rabbits, is highly specific to human SLFN11 and has been rigorously validated for use in Western blot and immunohistochemistry applications.SLFN11 is known for its role in regulating cellular response to chemotherapy and radiation therapy, making it a promising target for cancer treatment research. By enabling the detection and analysis of SLFN11 in various cell types, this antibody is essential for understanding the mechanisms underlying drug sensitivity and resistance in cancer cells.
Furthermore, SLFN11 has also been implicated in antiviral immune responses, highlighting its potential as a therapeutic target for viral infections. Research using this antibody holds promise for advancing our understanding of the role of SLFN11 in both cancer and viral pathogenesis, ultimately leading to the development of more effective treatment strategies.
Product Name:
SLFN11 Monoclonal Antibody
SKU:
CAB20809
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 132-328 of human SLFN11 (NP_689483.3).
Enables tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage.
Purification Method:
Affinity purification
Gene ID:
91607
Clone Number:
ARC51651
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of Jurkat, using SLFN11 antibody (CAB20809) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
