The Anti-SIRP Alpha Recombinant Rabbit Monoclonal Antibody (HDAB0220) is a cutting-edge tool for researchers studying SIRP Alpha, a key immune checkpoint protein involved in regulating immune responses. This antibody, developed in rabbits, offers high specificity and sensitivity for detecting SIRP Alpha in human samples, making it ideal for use in Western blot applications.SIRP Alpha, also known as signal regulatory protein alpha, is a critical molecule in immune modulation, playing a role in suppressing immune activation and promoting immune tolerance. Its function in immune regulation has significant implications for various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By targeting SIRP Alpha, researchers can gain valuable insights into immune dysregulation and potentially develop novel therapeutic strategies.With its superior performance and versatility, the Anti-SIRP Alpha Recombinant Rabbit Monoclonal Antibody (HDAB0220) is an essential tool for researchers investigating the complex interplay of immune checkpoints in health and disease. Its ability to specifically bind to SIRP Alpha protein makes it a valuable asset for studies in immunology, oncology, and autoimmune research. Order now and unlock new possibilities in your research endeavors.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
