The SHOX Polyclonal Antibody (CAB19517) is a valuable tool for researchers studying the SHOX gene, which plays a crucial role in skeletal development and growth regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blot and immunohistochemistry.The SHOX gene, located on the X and Y chromosomes, encodes a transcription factor that is essential for normal bone development and growth. Mutations in the SHOX gene have been associated with skeletal abnormalities such as short stature and skeletal dysplasia.
By targeting the SHOX protein, researchers can investigate the molecular mechanisms underlying these conditions and potentially develop targeted therapies for individuals affected by SHOX-related disorders.With its specificity and sensitivity, the SHOX Polyclonal Antibody is a valuable tool for advancing research in the fields of genetics, endocrinology, and developmental biology. Its ability to detect and analyze SHOX protein in various cell types makes it an ideal choice for studies seeking to unravel the complex processes regulating skeletal growth and development.
Product Name:
SHOX Rabbit Polyclonal Antibody
SKU:
CAB19517
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human SHOX (NP_000442.1).
This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
6473
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SHOX antibody (CAB19517) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
