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SHIP1 Rabbit Monoclonal Antibody (CAB3571)

SKU:
CAB3571
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SHIP
SHIP-1
SHIP1
SIP-145
hp51CN
p150Ship
Research Area:
Cell Death
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:SHIP1 Rabbit Monoclonal Antibody
SKU:CAB3571
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1084-1178 of human SHIP11 (Q92835).
Sequence:RSFT CSSS AEGR AAGG DKSQ GKPK TPVS SQAP VPAK RPIK PSRS EINQ QTPP TPTP RPPL PVKS PAVL HLQH SKGR DYRD NTEL PHHG KHRP EEG
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
Positive Sample:Raji, U-937
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:133kDa
Observed MW:145kDa

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:3635
Clone Number:ARC2047
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using SHIP11 Rabbit mAb (CAB3571) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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