The Anti-SHIP1 Antibody (CAB3571) is a highly specific tool for studying the SHIP1 protein, a phosphatase known for its role in immune regulation and cell signaling. This polyclonal antibody, produced in rabbits, is validated for use in various research applications, including Western blotting and immunofluorescence. It targets the SHIP1 protein, enabling accurate detection and analysis in a wide range of cell types.SHIP1, also known as SH2-containing inositol phosphatase 1, is a key regulator of immune cell function and is implicated in various diseases, including cancer and autoimmune disorders.
By investigating the function and localization of SHIP1 in cells, researchers can gain valuable insights into the mechanisms underlying immune responses and potential therapeutic targets. The Anti-SHIP1 Antibody is a valuable tool for advancing research in immunology and oncology, providing crucial information for the development of novel treatments and interventions.
Product Name:
SHIP1 Rabbit Monoclonal Antibody
SKU:
CAB3571
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1084-1178 of human SHIP11 (Q92835).
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3635
Clone Number:
ARC2047
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SHIP11 Rabbit mAb (CAB3571) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
