The Anti-SHH Antibody (CAB18863) offered by Assay Genie is a highly specific and sensitive tool for research involving Sonic Hedgehog (SHH), a key signaling protein involved in development, cell growth, and tissue repair. This polyclonal antibody is raised in rabbits and is validated for use in various applications, including Western blot and immunohistochemistry.SHH is a critical player in pathways regulating cell proliferation and differentiation, making it a valuable target for studies in developmental biology, cancer research, and regenerative medicine. This antibody binds specifically to SHH protein, enabling precise detection and analysis in a wide range of samples, making it an essential tool for researchers investigating the roles of SHH in different cellular processes.
Understanding the function of SHH and its regulatory roles in various biological processes is essential for developing new therapeutic strategies for a range of diseases, including cancer, neurodevelopmental disorders, and degenerative conditions. The Anti-SHH Antibody (CAB18863) is a reliable tool for researchers aiming to unravel the complex mechanisms involving SHH and its signaling pathways.
Product Name:
SHH Rabbit Polyclonal Antibody
SKU:
CAB18863
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 187-281 of mouse SHH (NP_033196.1).
Enables glycosaminoglycan binding activity; laminin-1 binding activity; and patched binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of T cell activation; and regulation of smooth muscle cell differentiation. Acts upstream of or within several processes, including animal organ development; limb morphogenesis; and neurogenesis. Located in several cellular components, including cell surface; extracellular space; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Used to study brachydactyly type A1 and holoprosencephaly 3. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule).
Purification Method:
Affinity purification
Gene ID:
20423
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SHH Rabbit pAb (CAB18863) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
