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SHANK3 Rabbit Polyclonal Antibody (CAB20488)

SKU:
CAB20488
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PSAP2
SCZD15
PROSAP2
SPANK-2
DEL22q13.3
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:SHANK3 Rabbit Polyclonal Antibody
SKU:CAB20488
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SHANK3 (NP_277052.1).
Sequence:MDGP GASA VVVR VGIP DLQQ TKCL RLDP AAPV WAAK QRVL CALN HSLQ DALN YGLF QPPS RGRA GKFL DEER LLQE YPPN LDTP LPYL EFRY KRRV YAQN LIDD KQFA KLHT KANL KKFM DYVQ LHST DKVA RLLD KGLD PNFH DPDS GE
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:PSAP2; SCZD15; PROSAP2; SPANK-2; DEL22q13.3; SHANK3
Positive Sample:Mouse brain
Conjugate:Unconjugated
Cellular Localization:ciliary membrane, cytosol, dendritic spine, neuron projection, neuron spine, postsynaptic density
Calculated MW:185kDa
Observed MW:220kDa

This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified.

Purification Method:Affinity purification
Gene ID:85358
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Mouse brain, using SHANK3 Rabbit pAb (CAB20488) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.

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