SHANK3 Rabbit Polyclonal Antibody (CAB20488)
- SKU:
- CAB20488
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PSAP2
- SCZD15
- PROSAP2
- SPANK-2
- DEL22q13.3
Description
Product Name: | SHANK3 Rabbit Polyclonal Antibody |
SKU: | CAB20488 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SHANK3 (NP_277052.1). |
Sequence: | MDGP GASA VVVR VGIP DLQQ TKCL RLDP AAPV WAAK QRVL CALN HSLQ DALN YGLF QPPS RGRA GKFL DEER LLQE YPPN LDTP LPYL EFRY KRRV YAQN LIDD KQFA KLHT KANL KKFM DYVQ LHST DKVA RLLD KGLD PNFH DPDS GE |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | PSAP2; SCZD15; PROSAP2; SPANK-2; DEL22q13.3; SHANK3 |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | ciliary membrane, cytosol, dendritic spine, neuron projection, neuron spine, postsynaptic density |
Calculated MW: | 185kDa |
Observed MW: | 220kDa |
This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified.
Purification Method: | Affinity purification |
Gene ID: | 85358 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |