The Anti-SFRP1 Antibody (CAB9656) is a valuable tool for research involving SFRP1, a secreted frizzled-related protein known for its role in regulating Wnt signaling pathways. This polyclonal antibody, produced in rabbits, is highly specific to human SFRP1 and is validated for use in Western blot applications. By binding to SFRP1, this antibody enables accurate detection and analysis of this protein in a variety of cell types, making it ideal for studies in developmental biology, cancer research, and stem cell regulation.
SFRP1 is a key player in modulating Wnt signaling, which is essential for various cellular processes such as cell proliferation, differentiation, and migration. Dysregulation of SFRP1 has been implicated in diseases such as cancer, osteoporosis, and neurodegenerative disorders, making it a promising target for therapeutic interventions. By studying the function and expression of SFRP1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic strategies.
Product Name:
SFRP1 Rabbit Monoclonal Antibody
SKU:
CAB9656
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SFRP1 (Q8N474).
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
Purification Method:
Affinity purification
Gene ID:
6422
Clone Number:
ARC1683
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SFRP1 Rabbit mAb (CAB9656) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.