The Serping1 Polyclonal Antibody (CAB19259) is a valuable tool for researchers studying Serping1, a key protein involved in the regulation of the complement system and inflammation. This antibody, produced in rabbits, has been validated for use in various applications, including Western blot analysis, making it ideal for investigating the role of Serping1 in immune responses and inflammatory pathways.Serping1, also known as C1 inhibitor, is a crucial regulator of the complement system, which plays a critical role in innate immunity and inflammation. Dysregulation of Serping1 has been implicated in various diseases, including hereditary angioedema and other inflammatory disorders.
By studying the expression and function of Serping1 using this specific antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the Serping1 Polyclonal Antibody (CAB19259) offers a reliable and effective tool for researchers interested in elucidating the role of Serping1 in immune regulation and inflammatory processes. Its high specificity and sensitivity make it a valuable asset for studies aimed at understanding the pathophysiology of immune-related diseases and developing targeted therapies.
Product Name:
SERPING1 Rabbit Monoclonal Antibody
SKU:
CAB19259
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SERPING1 (P05155).
Sequence:
SLKL YHAF SAMK KVET NMAF SPFS IASL LTQV LLGA GENT KTNL ESIL SYPK DFTC VHQA LKGF TTKG VTSV SQIF HSPD LAIR DTFV NASR TLYS SSPR V
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
C1IN; C1NH; HAE1; HAE2; C1INH; SERPING1
Positive Sample:
Human plasma,Mouse plasma,Rat plasma
Conjugate:
Unconjugated
Cellular Localization:
Secreted.
Calculated MW:
55kDa
Observed MW:
100kDa
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.
Purification Method:
Affinity purification
Gene ID:
710
Clone Number:
ARC2427
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SERPING1 Rabbit mAb (CAB19259) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
