The Anti-SEH1L Antibody (CAB20759) is a valuable tool for researchers studying SEH1L, a crucial component of the Nup107-160 nuclear pore subcomplex. This antibody, produced in rabbits, has been rigorously validated for use in applications such as Western blot and immunohistochemistry.SEH1L is essential for the assembly and stability of the nuclear pore complex, which controls the transport of molecules in and out of the cell nucleus. Dysregulation of SEH1L has been linked to various diseases, including cancer and developmental disorders.
By targeting SEH1L with this antibody, researchers can gain insights into its function and explore its potential as a therapeutic target.With its high specificity and sensitivity, the Anti-SEH1L Antibody is an invaluable tool for scientists investigating the role of SEH1L in cellular processes and disease pathology. Its versatility and reliability make it a must-have for studies in molecular biology, cell biology, and beyond.
Product Name:
SEH1L Polyclonal Antibody
SKU:
CAB20759
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 260-360 of human SEH1L (NP_112493.2).
cytosol, nuclear envelope, nuclear pore, nuclear pore outer ring
Calculated MW:
40kDa
Observed MW:
45kDa
The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
81929
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using SEH1L Rabbit pAb (CAB20759) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
