The Anti-SCN10A Antibody (CAB20459) is a valuable tool for researchers studying SCN10A, a gene involved in the regulation of cardiac sodium channel Nav1.8. This antibody, produced in rabbits, demonstrates high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the SCN10A protein, this antibody allows for the detection and analysis of Nav1.8 in various cell types, providing researchers with a deeper understanding of its role in cardiac function and potential implications in arrhythmias and other cardiovascular disorders.SCN10A, also known as Nav1.8, is a voltage-gated sodium channel that plays a crucial role in the generation and propagation of action potentials in cardiac tissues.
Dysregulation of Nav1.8 has been implicated in various cardiac conditions, including arrhythmias and conduction disorders. By studying the activity of SCN10A, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for cardiac diseases.Overall, the Anti-SCN10A Antibody (CAB20459) offers researchers a valuable tool for investigating the role of SCN10A in cardiac function and disease, with potential implications for the development of targeted therapies for cardiovascular disorders.
Product Name:
SCN10A Rabbit Polyclonal Antibody
SKU:
CAB20459
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1727-1956 of human SCN10A (NP_006505.3).
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6336
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of Neuro-2a cells using SCN10A Rabbit pAb (CAB20459) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
