The Anti-SARS-CoV Spike RBD Antibody (CAB20606) is a crucial tool for research involving the Spike receptor-binding domain (RBD) of the SARS-CoV virus. This antibody, produced in rabbits, is highly specific and reactive with samples from SARS-CoV-infected individuals, making it an essential asset in studying viral pathogenesis and developing diagnostics and therapeutics.The Spike RBD is a key component of the SARS-CoV virus that plays a vital role in viral entry into host cells. Understanding the interaction between the Spike RBD and host cell receptors is essential for unraveling the mechanisms of viral infection and developing effective countermeasures.
With its high specificity and sensitivity, the Anti-SARS-CoV Spike RBD Antibody (CAB20606) is an invaluable tool for researchers working on SARS-CoV and related coronaviruses. Its applications in immunohistochemistry, ELISA, and other experimental techniques make it a versatile reagent for various research needs in virology, infectious diseases, and public health. By targeting the Spike RBD, this antibody opens up new possibilities for studying the dynamics of SARS-CoV infection and designing interventions to combat this and other emerging coronaviruses.
Product Name:
SARS-CoV Spike RBD Rabbit Polyclonal Antibody
SKU:
CAB20606
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
SARS-CoV
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of coronavirus Spike RBD (NP_828851.1).
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.
Purification Method:
Affinity purification
Gene ID:
1489668
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SARS-CoV Spike RBD Rabbit pAb (CAB20606) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
