The Anti-SARS-CoV Spike Antibody (CAB20605) is a valuable tool for researchers studying the spike protein of the SARS-CoV virus, which is responsible for causing severe acute respiratory syndrome (SARS). This polyclonal antibody is specifically designed to target the spike protein, aiding in the detection and analysis of viral particles in various samples. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in applications such as Western blotting. Its ability to bind to the SARS-CoV spike protein makes it an essential tool for studying the structure and function of this key viral component, providing insights that can inform the development of diagnostics, treatments, and vaccines for SARS-CoV infections.
With the ongoing threat of coronaviruses, including SARS-CoV, understanding the spike protein and its interactions with host cells is crucial for combating these infectious diseases. The Anti-SARS-CoV Spike Antibody offers researchers a reliable means of studying this important viral target, advancing our knowledge of SARS-CoV biology and aiding in the development of strategies to control and prevent future outbreaks.
Product Name:
SARS-CoV Spike Rabbit Polyclonal Antibody
SKU:
CAB20605
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
SARS-CoV
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of coronavirus Spike (NP_828851.1).
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Purification Method:
Affinity purification
Gene ID:
1489668
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SARS-CoV Spike Rabbit pAb (CAB20605) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
