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SARS-CoV-2 NSP8 Rabbit Polyclonal Antibody (CAB20202)

SKU:
CAB20202
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Virus
Host Species:
Rabbit
Isotype:
IgG
€139 - €419

Description

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SARS-CoV-2 NSP8 Rabbit Polyclonal Antibody (CAB20202)

The Anti-SARS-CoV-2 NSP8 Antibody (CAB20202), a crucial tool for studying the NSP8 protein of the SARS-CoV-2 virus. This antibody is specifically designed for research purposes, particularly in the field of virology and infectious diseases. The antibody is highly reactive with human samples and has been validated for various applications, including Western blotting. By binding to the NSP8 protein, this antibody enables accurate detection and analysis of this key viral component in different cell types. Its specificity and reliability make it an essential tool for researchers studying the pathogenesis and potential treatments for COVID-19.The NSP8 protein is known to play a vital role in viral replication and the overall life cycle of the SARS-CoV-2 virus.

Understanding the function and characteristics of NSP8 is essential for developing effective antiviral therapies and vaccines to combat the COVID-19 pandemic. With this antibody, researchers can delve deeper into the molecular mechanisms of the virus and identify potential targets for intervention strategies.In conclusion, the Anti-SARS-CoV-2 NSP8 Antibody (CAB20202) is a valuable resource for investigating the SARS-CoV-2 virus and advancing our knowledge of its biology. Its high specificity and reliability make it a critical tool for research aimed at combating the ongoing global health crisis caused by COVID-19.

Product Name:SARS-CoV-2 NSP8 Rabbit Polyclonal Antibody
SKU:CAB20202
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:SARS-CoV-2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of coronavirus NSP8 (YP_009742615.1).
Sequence:AIAS EFSS LPSY AAFA TAQE AYEQ AVAN GDSE VVLK KLKK SLNV AKSE FDRD AAMQ RKLE KMAD QAMT QMYK QARS EDKR AKVT SAMQ TMLF TMLR KLDN DALN NIIN NARD GCVP LNII PLTT AAKL MVVI PDYN TYKN TCDG TTFT YASA LWEI QQVV DADS KIVQ LSEI SMDN SPNL AWPL IVTA LRAN SAVK LQ
Tested Applications:WB ELISA
Recommended Dilution:WB,1:2000 - 1:10000
Positive Sample:293T
Calculated MW:141kDa
Observed MW:25kDa

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

Purification Method:Affinity purification
Gene ID:43740578
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of normal 293T cells and 293T transfected with NSP8 Protein, using SARS-CoV-2 NSP8 Rabbit pAb (CAB20202) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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