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SARS-CoV-2 NSP2 Rabbit Polyclonal Antibody (CAB20280)

SKU:
CAB20280
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Virus
Host Species:
Rabbit
Isotype:
IgG
€139 - €419
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Description

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SARS-CoV-2 NSP2 Rabbit Polyclonal Antibody (CAB20280)

The Anti-SARS-CoV-2 NSP2 Antibody (CAB20280) is a highly specific antibody designed for research involving the NSP2 protein of the SARS-CoV-2 virus. This polyclonal antibody is raised in rabbits and is highly reactive with samples from SARS-CoV-2 infected individuals, making it a valuable tool for studying the viral protein.NSP2 is a non-structural protein of the SARS-CoV-2 virus that plays a critical role in viral replication and pathogenesis. By targeting the NSP2 protein, researchers can gain insights into the mechanisms of SARS-CoV-2 infection and potentially identify new therapeutic targets for combating the virus.

The Anti-SARS-CoV-2 NSP2 Antibody is validated for use in various applications, including Western blotting and immunofluorescence, enabling researchers to detect and analyze the NSP2 protein in different cell types. This antibody is an essential tool for advancing research in virology and developing new strategies for diagnosing and treating COVID-19.

Product Name:SARS-CoV-2 NSP2 Rabbit Polyclonal Antibody
SKU:CAB20280
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:SARS-CoV-2
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 150-250 of coronavirus NSP2 (YP_009742609.1).
Sequence:SWQT GDFV KATC EFCG TENL TKEG ATTC GYLP QNAV VKIY CPAC HNSE VGPE HSLA EYHN ESGL KTIL RKGG RTIA FGGC VFSY VGCH NKCA YWVP RASA N
Tested Applications:WB ELISA
Recommended Dilution:WB,1:2000 - 1:6000
Positive Sample:293T
Calculated MW:794kDa
Observed MW:75kDa

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF1ab, the largest gene, contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. Production of the longer (PP1ab) or shorter protein (PP1a) depends on a -1 ribosomal frameshifting event. The proteins, based on similarity to other coronaviruses, include the papain-like proteinase protein (NSP3), 3C-like proteinase (NSP5), RNA-dependent RNA polymerase (NSP12, RdRp), helicase (NSP13, HEL), endoRNAse (NSP15), 2'-O-Ribose-Methyltransferase (NSP16) and other nonstructural proteins. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies.

Purification Method:Affinity purification
Gene ID:43740578
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of normal 293T cells and 293T transfected with NSP2 Protein, using SARS-CoV-2 NSP2 Rabbit pAb (CAB20280) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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