The Ring1A Monoclonal Antibody (CAB20171) is a valuable tool for researchers studying Ring1A, a key protein involved in epigenetic regulation and gene expression. This antibody, produced in mice, is highly specific and reactive with Ring1A in human samples, making it ideal for Western blot and immunohistochemistry applications. Ring1A is a crucial component of the Polycomb Repressive Complex 1 (PRC1) and plays a pivotal role in chromatin remodeling and transcriptional regulation. Dysregulation of Ring1A has been linked to various diseases, including cancer and developmental disorders.
By targeting Ring1A with this antibody, researchers can gain insights into its function and potential therapeutic implications in these pathological conditions. With its high specificity and sensitivity, the Ring1A Monoclonal Antibody (CAB20171) is a valuable tool for investigating the role of Ring1A in epigenetic regulation and disease development. Its applications in research extend to fields such as oncology, developmental biology, and epigenetics, making it an essential reagent for scientists exploring the complex mechanisms of gene regulation.
Product Name:
RING1A Rabbit Polyclonal Antibody
SKU:
CAB20171
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 207-406 of human RING1A A (NP_002922.2).
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.
Purification Method:
Affinity purification
Gene ID:
6015
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RING1A Rabbit pAb (CAB20171) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
