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Anti-RhoGAP Antibody (CAB2330)

SKU:
CAB2330
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GFI2
RhoGAP5
p190-B
p190BRhoGAP
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Anti-RhoGAP Antibody (CAB2330)

The RhoGAP Polyclonal Antibody (CAB2330) is a valuable tool for researchers studying the RhoGAP protein, a key regulator of cell migration and cytoskeletal dynamics. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the RhoGAP protein, it allows for the detection and analysis of RhoGAP expression in a variety of cell types, making it ideal for studies in cell biology and cancer research.RhoGAP is a crucial player in cellular processes such as cell adhesion, motility, and division, making it a promising target for research in cancer metastasis and other diseases characterized by abnormal cell migration.

Understanding the function of RhoGAP is essential for developing therapies that target these processes and potentially inhibit disease progression. The RhoGAP Polyclonal Antibody offers a reliable tool for researchers seeking to investigate the role of RhoGAP in cellular function and disease development.

Product Name:RhoGAP Rabbit mAb
Product Code:CAB2330
Size:20uL, 50uL, 100uL
Synonyms:GFI2, RhoGAP5, p190-B, p190BRhoGAP
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RhoGAP
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, MCF7, C2C12, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human RhoGAP
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:394
Uniprot:Q13017
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:190kDa
Observed MW:190kDa
UniProt Protein Function:ARHGAP5: a GTPase activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of p120GAP. Negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP.
UniProt Protein Details:

Protein type:GAPs; Motility/polarity/chemotaxis; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function:GTPase activity; protein binding; GTP binding; SH2 domain binding

Biological Process: regulation of small GTPase mediated signal transduction; mammary gland development; metabolic process; small GTPase mediated signal transduction; positive regulation of mesenchymal cell proliferation; cell adhesion; regulation of cell size; Rho protein signal transduction; positive regulation of cell migration

NCBI Summary:Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13017
NCBI GenInfo Identifier:190358871
NCBI Gene ID:394
NCBI Accession:Q13017.2
UniProt Related Accession:Q13017
Molecular Weight:
NCBI Full Name:Rho GTPase-activating protein 5
NCBI Synonym Full Names:Rho GTPase activating protein 5
NCBI Official Symbol:ARHGAP5  
NCBI Official Synonym Symbols:GFI2; p190-B; RhoGAP5; p190BRhoGAP  
NCBI Protein Information:rho GTPase-activating protein 5
UniProt Protein Name:Rho GTPase-activating protein 5
UniProt Synonym Protein Names:Rho-type GTPase-activating protein 5; p190-B
UniProt Gene Name:ARHGAP5  
UniProt Entry Name:RHG05_HUMAN

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