The RAP1A/RAP1B Polyclonal Antibody (CAB9725) is a valuable tool for research involving RAP1A and RAP1B, small GTPases that play important roles in cell adhesion, migration, and proliferation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to RAP1A and RAP1B proteins, researchers can accurately detect and analyze these critical signaling molecules in various cell types, making it a versatile option for studies in cell biology and cancer research.RAP1A and RAP1B are key regulators of cell adhesion and migration, influencing processes such as cell spreading, cell-cell adhesion, and cell-extracellular matrix interactions.
Dysregulation of RAP1 signaling has been implicated in various diseases, including cancer, cardiovascular disorders, and developmental abnormalities. Therefore, investigating the functions of RAP1A and RAP1B is important for understanding the underlying molecular mechanisms of these conditions and identifying potential therapeutic targets.By utilizing the RAP1A/RAP1B Polyclonal Antibody (CAB9725), researchers can explore the roles of these GTPases in cellular processes and disease pathogenesis, ultimately contributing to the development of novel treatment strategies and diagnostic tools.
Product Name:
RAP1A + RAP1B Rabbit Monoclonal Antibody
SKU:
CAB9725
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-150 of human RAP1A + RAP1B (P61224).
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Purification Method:
Affinity purification
Gene ID:
5908/5906
Clone Number:
ARC1719
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RAP1A + RAP1B Rabbit mAb (CAB9725) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
