The RAIDD/CRADD Polyclonal Antibody (CAB8664) is a valuable tool for researchers studying the RAIDD/CRADD protein, which plays a key role in apoptotic signaling pathways. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the RAIDD/CRADD protein, this antibody enables accurate detection and analysis of this critical protein in various cell types.RAIDD/CRADD is a crucial component of the apoptosis pathway, acting as an adaptor molecule that links death receptors to downstream caspases.
Dysregulation of this pathway has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. Understanding the function of RAIDD/CRADD is essential for uncovering potential therapeutic targets for these diseases.By using the RAIDD/CRADD Polyclonal Antibody (CAB8664), researchers can gain valuable insights into the molecular mechanisms underlying apoptosis and develop innovative strategies for targeted therapies. This antibody is an indispensable tool for studies in cell biology, cancer research, and drug development.
Product Name:
RAIDD/CRADD Rabbit Monoclonal Antibody
SKU:
CAB8664
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-150 of human CRADD (P78560).
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8738
Clone Number:
ARC1771
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RAIDD/CRADD Rabbit mAb (CAB8664) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
