The Anti-RAIDD/CRADD Antibody (CAB8663) is a highly specific tool for researchers studying the RAIDD/CRADD protein, which plays a crucial role in apoptosis and immune signaling pathways. This polyclonal antibody, produced in rabbits, shows strong reactivity with human samples and is validated for use in Western blot applications. By targeting the RAIDD/CRADD protein, this antibody enables detection and analysis in various cell types, making it a valuable tool for studies in cell biology, immunology, and cancer research.RAIDD/CRADD, also known as the CRADD protein or CASP2 and RIPK1 domain containing adaptor with death domain, is a key regulator of apoptotic cell death and immune signaling.
Its involvement in these pathways makes it a promising target for research in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Understanding the functions and interactions of RAIDD/CRADD is essential for developing targeted therapies aimed at modulating apoptotic pathways and immune responses in these disease contexts.
Product Name:
RAIDD/CRADD Rabbit Monoclonal Antibody
SKU:
CAB8663
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-199 of human RAIDD/CRADD (NP_003796.1).
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8738
Clone Number:
ARC1770
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RAIDD/CRADD Rabbit mAb (CAB8663) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
