The Anti-PYCARD Antibody (CAB20484) is an essential tool for researchers studying the PYCARD protein, also known as Asc (Apoptosis-associated speck-like protein containing a caspase recruitment domain). This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot and immunofluorescence applications.The PYCARD protein plays a key role in the formation of inflammasomes, large protein complexes that activate inflammatory responses in the body. Dysregulation of inflammasome activation has been linked to various inflammatory diseases, making PYCARD an attractive target for therapeutic interventions.
By binding specifically to PYCARD, this antibody enables precise detection and analysis of PYCARD expression in different cell types, providing valuable insights for studies in immunology, inflammation, and disease pathology.Researchers investigating the molecular mechanisms underlying inflammatory processes, autoimmune disorders, and infectious diseases will benefit from using the Anti-PYCARD Antibody (CAB20484) as a reliable tool for their experiments. Its specificity and sensitivity make it a valuable asset for elucidating the complex regulatory networks involving PYCARD and its role in driving inflammatory responses.
Product Name:
PYCARD Rabbit Polyclonal Antibody
SKU:
CAB20484
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of mouse ASC/TMS1 (NP_075747.3).
Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including activation of cysteine-type endopeptidase activity; positive regulation of cytokine production; and regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of macromolecule metabolic process; and regulation of autophagy. Located in cytosol; extracellular region; and nucleus. Part of inflammasome complex. Is expressed in several structures, including alimentary system; brain; heart; hemolymphoid system gland; and urinary system. Orthologous to human PYCARD (PYD and CARD domain containing).
Purification Method:
Affinity purification
Gene ID:
66824
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ASC/TMS1 Rabbit pAb (CAB20484) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
