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PYCARD Rabbit Polyclonal Antibody (CAB20484)

SKU:
CAB20484
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
A
Asc
TMS-
TNS1
masc
CARD5
TMS-1
9130417A21Rik
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PYCARD Rabbit Polyclonal Antibody
SKU:CAB20484
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of mouse ASC/TMS1 (NP_075747.3).
Sequence:MGRA RDAI LDAL ENLS GDEL KKFK MKLL TVQL REGY GRIP RGAL LQMD AIDL TDKL VSYY LESY GLEL TMTV LRDM GLQE LAEQ LQTT KEES G
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:Asc; TNS1; masc; CARD5; TMS-1; 9130417A21Rik; ASC/TMS1
Positive Sample:THP-1,U-937,Mouse spleen,Mouse thymus,Rat spleen,Rat thymus
Conjugate:Unconjugated
Cellular Localization:AIM2 inflammasome complex, cytoplasm, cytosol, endoplasmic reticulum, extracellular region, IkappaB kinase complex, inflammasome complex, mitochondrion, NLRP1 inflammasome complex, NLRP3 inflammasome complex, NLRP6 inflammasome complex, nucleolus, nucleoplasm, nucleus
Calculated MW:21kDa
Observed MW:25kDa

Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including activation of cysteine-type endopeptidase activity; positive regulation of cytokine production; and regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of macromolecule metabolic process; and regulation of autophagy. Located in cytosol; extracellular region; and nucleus. Part of inflammasome complex. Is expressed in several structures, including alimentary system; brain; heart; hemolymphoid system gland; and urinary system. Orthologous to human PYCARD (PYD and CARD domain containing).

Purification Method:Affinity purification
Gene ID:66824
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using ASC/TMS1 Rabbit pAb (CAB20484) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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