PSMA Rabbit Monoclonal Antibody (CAB9547)
- SKU:
- CAB9547
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- FGCP
- FOLH
- GCP2
- GCPII
- NAALAD1
- NAALAdase
- PSM
- PSMA
- mGCP
- Research Area:
- Cell Biology
Description
Product Name: | PSMA Rabbit Monoclonal Antibody |
SKU: | CAB9547 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human PSMA/FOLH1 (Q04609). |
Sequence: | MWNL LHET DSAV ATAR RPRW LCAG ALVL AGGF FLLG FLFG WFIK SSNE ATNI TPKH NMKA FLDE LKAE NIKK FLYN FTQI PHLA GTEQ NFQL AKQI QSQW KEFG LD |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IF/ICC,1:50 - 1:200 |
Synonyms: | PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; PSMA/FOLH1 |
Positive Sample: | LNCaP |
Conjugate: | Unconjugated |
Cellular Localization: | cell surface, cytoplasm, extracellular exosome, plasma membrane |
Calculated MW: | 84kDa |
Observed MW: | 100kDa |
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 2346 |
Clone Number: | ARC1628 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |