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Pseudouridine/5-ribosyluracil Monoclonal Antibody (CAB20988)

SKU:
CAB20988
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
$215 - $563
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Pseudouridine/5-ribosyluracil Monoclonal Antibody
SKU:CAB20988
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Species independent
Immunogen:Chemical compounds corresponding to Pseudouridine / 5-ribosyluracil / Y.
Tested Applications:ELISA DB
Recommended Dilution:DB,1:500 - 1:1000
Positive Sample:Pseudouridine / 5-ribosyluracil
Observed MW:Refer to figures

Pseudouridine (Ψ) was among the first post-transcriptional modifications discovered and is overall one of the most abundant（1）. It is present in a wide range of cellular RNAs and is highly conserved across species. Ψ is derived from uridine (U) via base-specific isomerization catalyzed by Ψ synthases. The site-specific pseudouridylation goes through either snoRNA-dependent (requires H/ACA RNP) or -independent mechanism (requires pseudouridine synthase (PUS) family enzymes)（2）. It has an extra hydrogen-bond donor at its non-Watson-Crick edge. When incorporated into RNA, Ψ can alter RNA secondary structure by increasing base stacking, improving base pairing and rigidifying sugar-phosphate backbone5. The chemical and physical properties of RNA can be altered with the incorporation of Ψ, which could contribute to subsequent cellular functions.

Purification Method:Affinity purification
Gene ID:CAS: 1445-07-4
Clone Number:ARC50719
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageDot-blot analysis of different sorts of chemical compounds using Pseudouridine / 5-ribosyluracil Rabbit mAb (CAB20988) at 1:1000 dilution.

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