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PSA/KLK3 Rabbit Monoclonal Antibody (CAB4355)

SKU:
CAB4355
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
APS
KLK2A1
PSA
hK3
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PSA/KLK3 Rabbit Monoclonal Antibody
SKU:CAB4355
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 162-261 of human PSA/KLK3 (P07288).
Sequence:PEEF LTPK KLQC VDLH VISN DVCA QVHP QKVT KFML CAGR WTGG KSTC SGDS GGPL VCNG VLQG ITSW GSEP CALP ERPS LYTK VVHY RKWI KDTI VANP
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:APS; PSA; hK3; KLK2A1; PSA/KLK3
Positive Sample:LNCaP
Conjugate:Unconjugated
Cellular Localization:extracellular exosome, extracellular region, extracellular space, nucleus
Calculated MW:29kDa
Observed MW:30kDa

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.

Purification Method:Affinity purification
Gene ID:354
Clone Number:ARC0976
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of LNCaP cells, using PSA/KLK3 antibody (CAB4355) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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