The Anti-Proteinase 3 (PR3) Antibody (CAB19748) is a crucial tool for researchers studying proteinase 3, an enzyme involved in immune response and inflammation regulation. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the proteinase 3 molecule, the antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in immunology and autoimmune diseases.
Proteinase 3, also known as PR3, plays a pivotal role in immune regulation by modulating inflammation and immune responses. Its involvement in various diseases, including autoimmune disorders and chronic inflammatory conditions, makes it a key target for research aimed at developing new therapies and treatments. Understanding the function and activity of proteinase 3 is vital for advancing our knowledge of immune system dysregulation and finding potential interventions for related health issues.
Product Name:
PR3 Rabbit Monoclonal Antibody
SKU:
CAB19748
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Proteinase 3/PR3 (P24158).
Enables enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Located in azurophil granule lumen; cytosol; and plasma membrane raft. Colocalizes with plasma membrane.
Purification Method:
Affinity purification
Gene ID:
5657
Clone Number:
ARC2275
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using Proteinase 3/PR3 Rabbit mAb (CAB19748) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
