The Anti-PON1 Antibody (CAB3441) is a high-quality polyclonal antibody designed for research involving PON1, a crucial enzyme involved in antioxidant defense and lipid metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blotting and immunohistochemistry.PON1, also known as Paraoxonase 1, is an enzyme primarily associated with protecting against oxidative stress and inflammation by breaking down harmful lipid peroxides. Its role in regulating lipid metabolism and preventing the formation of atherosclerotic plaques makes it a key player in cardiovascular health and disease.
Research into PON1 is essential for understanding its impact on various health conditions and developing therapeutic interventions targeting oxidative stress and lipid-related disorders.The Anti-PON1 Antibody (CAB3441) enables accurate detection and analysis of PON1 expression levels in different cell types and tissues, making it a valuable tool for studies in cardiovascular biology, metabolic disorders, and oxidative stress-related diseases. Its specificity and sensitivity make it a reliable option for researchers looking to further explore the functions and mechanisms of PON1 in health and disease.
Product Name:
PON1 Rabbit Monoclonal Antibody
SKU:
CAB3441
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PON1 (P27169).
This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7.
Purification Method:
Affinity purification
Gene ID:
5444
Clone Number:
ARC2001
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using PON1 Rabbit mAb (CAB3441) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
